Factors Responsible Or Causes of Tolerance and Tachyphylaxis Of Drugs in Pharmaology An injectable hydroxyapatite microsphere filler loaded with GHK Cu tripeptide for anti Inflammatory and antioxidant ScienceDirect 16. Receptor Regulation Principles of Pharmacology Study Guide Glycyl L histidyl L lysine Cu2+ (GHK Cu) Attenuates CuSO4 or LPS induced inflammation in Zebrafish larvae model ScienceDirect Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a TOLERANCE & TACHYPHYLAXIS