What Caused These Multiple Hyperpigmented Macules of the Mouth? An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Lip Melanotic Macule Holistic Removal TikTok Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update Melanotic Macule Lip Removal TikTok This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips.