Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which sagesteele @P_McCulloughMD While I dont know whether there is a connection between Tylenol and autism, I do believe that there is reason to STOP giving it to babies children. Glutathione is impacted by Frontiers Liquid Chromatography Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S Transferases Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA