As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. N acetylcysteine (NAC) About Acetaminophen Overdose Full article: The development and hepatotoxicity of acetaminophen: reviewing over a century of progress g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram