Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Sex differences in glutathione metabolism and acetaminophen toxicity View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Paracetamol (Acetaminophen) and the Developing Brain